Irina Kareva, PhD
of Cancer Systems Biology
St. Elizabeth's Medical Center
Tufts University School of Medicine
736 Cambridge Street
Boston, MA, 02135
2009-2011 Ph.D. Applied Mathematics in Life and
Social Sciences (AMLSS),
Arizona State University
Construction, Sustainability and Evolutionary Ecology of
2003-2008 B.S. Mathematics / B.A.
University of Maryland/College Park
2004-2005 Universität Wien,
Vienna, Austria (study abroad)
Ecology, evolution, mathematical modeling, game theory, cancer
as an evolving ecological system, metabolism, Warburg effect,
consequences of population heterogeneity, parameter
Kareva, I. and P. Hahnfeldt (2013). The
Emerging "Hallmarks" of Metabolic Reprogramming and
Immune Evasion: Distinct or Linked? Cancer
Research, 73(9): 2737-42.
Kareva, I., Berezovskaya, F. and
G. Karev (2013). Mixed Strategies and Natural Selection in
Ecological Niche Construction, Mathematical
Biosciences and Engineering, accepted.
Stoichiometry in Tumor Microenvironments (2013). PloS
doi: 10.1371/journal.pone.0051844. Epub 2013 Jan 22.
Kareva, I., Morin, B. and G. Karev (2013). Preventing
the tragedy of the commons through punishment of over-consumers
and encouragement of under-consumers. Bulletin of
Mathematical Biology, 2013 Feb 14. [Epub ahead of print].
Kareva, I., Berezovskaya, F. and C. Castillo-Chavez
construction and sustainability in resource-dependent
competition models. Mathematical Biosciences, 240(2): 114-123.
Kareva, I. (2011) Prisoner's
dilemma in cancer metabolism. PloS ONE, doi:10.1371/journal.pone.0028576
Kareva, I. (2011) "What
can ecology teach us about cancer?" Translational
Oncology, 4(5), 266-270.
Redon, C., Dickey, J., Nakamura, A., Kareva,
I., Naf, D., Nowsheen, S., Kryston, T., Bonner, W.,
Georgakilas, A., Sedelnikova, O. (2010) Tumors
induce complex DNA damage in distant proliferative
tissues in vivo. PNAS, 107(42),17992-17997.
Kareva, I., Berezovskaya, F., and C. Castillo-Chavez (2009). Myeloid
cells in tumour–immune interactions. Journal of
Biological Dynamics, 4(4), 315-327.
Colon-Rentas, O., Kareva, I., Reitsman, P., Toutain, G., and
S. Crook (2007) A
Mathematical Model of the Heart of Drosophila melanogaster.
MTBI Technical Reports, Arizona State University.
Ogurtsov, A., Kareva I., Spiridonov,
T., and A. Kondrashov (2003) PostOWEN: Computational approach to the analysis of genomic alignments. Fourth
International Conference on Bioinformatics, Atlanta, Nov.
In preparation/under review:
Kareva, I., Wilkie K. and P.
Hahnfeldt. "The Power of the Tumor Microenvironment: a
Systemic Approach for a Systemic Disease".
Kareva, I. and P. Hahnfeldt.
"Immune Evasion through Competitive Inhibition: the
Shielding Effect of Cancer non-Stem Cells".
Kareva, I., Beheshti, A. and P.
Hahnfeldt. "Competition Driven Cancer Immunoediting."
Professional Development Workshops,
Internships and Conferences
Upcoming: Center of
Cancer Systems Biology Annual Workshop: Cancer-Host
Interactions. July 16-19, Boston, MA
Cancer Institute's Integrative Cancer Biology Program - Annual
Principal Investigators Meeting, May 6-8, Rockville, MD
Modelling Biological Evolution 2013: Recent Progress, Current
Challenges and Future Directions, May 1-3, Leicester, UK
Biology of Tumor Metronomics: Timing and Dose Level Dynamics,
July 17-20, 2012, Boston, MA
Society of Mathematical Biology Annual Meeting, July 25-28, 2012,
Knoxville, TN. Invited speaker at the Cancer Immunology
Title: "Competition driven cancer immunoediting".
cell-based modeling workshop, January 4-6, Oxford, UK
The 3rd International Conference on Mathematical
Modeling and Analysis of Populations of Biological Systems (ICMAIII), San
Antonio, Texas, October 7-9, 2011.
Workshop for Young Researchers in Mathematical Biology,
Columbus, Ohio, August 29-September 1, 2011.
International Conference for Industrial and
Applied Mathematics (ICIAM
2011), Vancouver, Canada, July 14-16, 2011 (Talk:
“Prisoner’s Dilemma in Cancer Metabolism”)
Conference on Mathematical and Theoretical Biology, June
28-July 3, 2011
Investigative Workshop: Mathematical Models and Body Weight
Regulation, July 12-15, 2011
July 18-22, 2011
Rotation in the Maley Lab at
Hellen Diller Comprehensive Cancer Center, UCSF. January-April
Biocomplexity XI. The Evolution of
Cooperation: Paradoxes of Collectivity and Individuality.
Bloomington, Indiana, December 3-5, 2010
The Helsinki Summer School on Mathematical
Ecology and Evolution, August 22nd-29th, 2010
Joint CAMBAM-MBI Summer School on
“Networks in Biological Networks”, Montreal, Canada, May
Summer internship in the Moult
Lab at the Institute for Bioscience and Biotechnology
Research (IBBR) at the University of Maryland, College Park.
Worked on understanding mixed distributions that underlie data
on single nucleotide polymorphisms (SNPs) in different
Winter course on “Delay Equations and Structured
Population Models”, Basque Center for Applied Mathematics,
Derio, Spain, January 2010 http://www.bcamath.org/public_courses/ctrl_courses.php
Summer school “Dynamical Systems and Their Applications”.
Utrecht, Netherlands, 17-28th August 2009 http://www.utrechtsummerschool.nl/
Summer school “Mathematical
Modeling, Non-linear Dynamics, Stochastic and Complex
Systems”. Lyngby, Denmark, 8-15th August, 2009
Summer internship at the Laboratory of Integrative and
Medical Biophysics, National Center for Child Health and Human
Development, NIH. Analyzed images of human retina using ImageJ
software. PI: Dr. R. Bonner http://2006annualreport.nichd.nih.gov/limb.htm
Laboratory assistant, Laboratory of Molecular
Pharmacology, National Cancer Institute, NIH. Prepared slides
for immunocytochemistry; cell culture, Western blotting, data
collection and statistical analysis.
PI: Dr. W. Bonner http://www3.cancer.gov/intra/lmp/lmppage.htm
Summer internship at the Mathematical and Theoretical
Biology Institute (MTBI), ASU. Projects involved cancer-immune
system modeling, and neural modeling.
Director: Dr. C. Castillo-Chavez http://mtbi.asu.edu/
Summer internship at National Center for
Bioinformatics, NIH. Performed genome comparisons using online
databases and Owen software. PI: Dr. A. Kondrashov
Teaching Assistant for Introduction to Probability (aml294),
Teaching Assistant for Inorganic Chemistry Lab (chem132), UMD
American Association for Cancer
Research (AACR), since 2012
Society of Mathematical Biology (SMB),
corrected typos, suggestions for better phrasing are very
Molchanov, A.M. "Possible
Roles of Oscillatory Processes in Evolution"
Molchanov, A.M. "Thermodynamics
Molchanov, A.M. "Time
Molchanov, A.M. "Models
Molchanov, A.M. "Extreme
Russian (native), English (fluent), French (communication
level), German (communication level)
CV in pdf format